@article{TRO4214,
author = {Yu-Yen Chen and Yao-Te Tsai and Ming-Shao Tsai and Cheng-Ming Hsu and Chia-Hsuan Lai and Chang-Hsien Lu and Ping-Tsung Chen and Fu-Min Fang and Miao-Fen Chen and Wen-Cheng Chen},
title = {Treatment outcomes of locally advanced hypopharyngeal squamous cell carcinoma},
journal = {Therapeutic Radiology and Oncology},
volume = {2},
number = {4},
year = {2018},
keywords = {},
abstract = {Background: The primary treatment for advanced-stage (stage III–IVB) hypopharyngeal squamous cell carcinoma (HPSCC) includes primary surgery followed by either adjuvant radiotherapy (RT) or adjuvant chemo-radiotherapy (CCRT) or definitive CCRT. However, the optimal primary treatment for advanced HPSCC remains controversial. In the present study, we intend to compare the outcome of primary surgery versus definitive CCRT and try to identify the optimal treatment for advanced-stage hypopharyngeal cancer.
Methods: We performed a retrospective analysis of newly diagnosed patients with stage III, IVA and IVB HPSCC at the southern branches (Chiayi and Kaohsiung) of Chang Gung Memorial Hospital between September 2002 and September 2013. The 5-year overall survival (OS), disease-free survival (DFS), loco-regional recurrence rate (LRR) and distant-metastasis rate (DMR) were analyzed and compared between primary surgery and definitive CCRT groups.
Results: We enrolled 367 consecutive patients in this retrospective study. 110 patients who did not meet the study's criteria were excluded from analysis. Among the 257 patients included, 133 patients were treated with primary surgery (the SX group) and 124 patients were treated with definitive CCRT (the CCRT group). With a median follow-up time of 5.83 years for surviving patients, the 5-year OS (53% vs. 32%, P},
issn = {2616-2768}, url = {https://tro.amegroups.org/article/view/4214}
}