TY  - JOUR
AU  - Chen, Wei
AU  - Xue, Jing-Yue
AU  - Wang, Victoria J.
PY  - 2026
TI  - Relative cerebral blood volume and fractional anisotropy for differentiating recurrent glioma from radiation injury: a systematic review
JF  - Therapeutic Radiology and Oncology; Vol 10 (June 30, 2026): Therapeutic Radiology and Oncology
Y2  - 2026
KW  - 
N2  - Background: Glioma recurrence usually indicates a poorer prognosis and impacts survival prediction, while radiation necrosis may be reversible or non-progressive. To address this challenge and guide appropriate clinical decisions, advanced imaging modalities and biomarkers are being used to non-invasively assess lesion characteristics and improve diagnostic accuracy. This advanced imaging modalities include relative cerebral blood volume (rCBV) in perfusion magnetic resonance imaging (MRI) and fractional anisotropy (FA) in diffusion tensor imaging (DTI). However, the value of rCBV and FA in evaluation of glioma recurrence and radiation injury was rarely studied. The aim is to explore the value of rCBV and FA towards differentiating recurrent glioma from radiation injury.Methods: Published studies related to the perfusion MRI and DTI of recurrent glioma and radiation injury were retrieved from PubMed, Cochrane Library and Web of Science database before 1 September 2025. Data extraction results were managed using Excel for a meta-analysis. Newcastle-Ottawa scale was used to assess the quality of included studies. Pooling data synthesis was completed using the Review Manager 5.4 software with a random effect model.Results: Eighteen qualified studies were used for qualitative and quantitative data synthesis. The rCBV was higher in the recurrent glioma group than the one in the radiation injury group [standardized mean difference (SMD) =1.48, 95% confidence interval (CI): 1.13, 1.84, P
UR  - https://tro.amegroups.org/article/view/10553